Regulatory R region of the CFTR chloride channel is a dynamic integrator of phospho-dependent intra- and intermolecular interactions

Intrinsically disordered proteins play crucial roles in regulatory processes and often function as protein interaction hubs. Here, we present a detailed characterization of a full-length disordered hub protein region involved in multiple dynamic complexes. We performed NMR, CD, and fluorescence bind...

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Bibliographische Detailangaben
Hauptverfasser: Bozoky, Zoltan, Krzeminski, Mickael, Muhandiram, Ranjith, Birtley, James R., Al-Zahrani, Ateeq, Thomas, Philip J., Frizzell, Raymond A., Ford, Robert C., Forman-Kay, Julie D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2013
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3839774/
https://ncbi.nlm.nih.gov/pubmed/24191035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1315104110
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