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ADP-ribosyl-acceptor hydrolase 3 regulates poly (ADP-ribose) degradation and cell death during oxidative stress

Poly (ADP ribose) (PAR) formation catalyzed by PAR polymerase 1 in response to genotoxic stress mediates cell death due to necrosis and apoptosis. PAR glycohydrolase (PARG) has been thought to be the only enzyme responsible for hydrolysis of PAR in vivo. However, we show an alternative PAR-degradati...

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Bibliografske podrobnosti
Main Authors: Mashimo, Masato, Kato, Jiro, Moss, Joel
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3839768/
https://ncbi.nlm.nih.gov/pubmed/24191052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1312783110
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