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Mechanistic picture for conformational transition of a membrane transporter at atomic resolution

During their transport cycle, ATP-binding cassette (ABC) transporters undergo large-scale conformational changes between inward- and outward-facing states. Using an approach based on designing system-specific reaction coordinates and using nonequilibrium work relations, we have performed extensive a...

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Hlavní autoři: Moradi, Mahmoud, Tajkhorshid, Emad
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3839739/
https://ncbi.nlm.nih.gov/pubmed/24191018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1313202110
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