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Mechanistic picture for conformational transition of a membrane transporter at atomic resolution
During their transport cycle, ATP-binding cassette (ABC) transporters undergo large-scale conformational changes between inward- and outward-facing states. Using an approach based on designing system-specific reaction coordinates and using nonequilibrium work relations, we have performed extensive a...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3839739/ https://ncbi.nlm.nih.gov/pubmed/24191018 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1313202110 |
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