Error rates for nanopore discrimination among cytosine, methylcytosine, and hydroxymethylcytosine along individual DNA strands

Cytosine, 5-methylcytosine, and 5-hydroxymethylcytosine were identified during translocation of single DNA template strands through a modified Mycobacterium smegmatis porin A (M2MspA) nanopore under control of phi29 DNA polymerase. This identification was based on three consecutive ionic current sta...

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Bibliographic Details
Main Authors: Schreiber, Jacob, Wescoe, Zachary L., Abu-Shumays, Robin, Vivian, John T., Baatar, Baldandorj, Karplus, Kevin, Akeson, Mark
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2013
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3839712/
https://ncbi.nlm.nih.gov/pubmed/24167260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1310615110
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