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PRC2 binds to active promoters and contacts nascent RNAs in embryonic stem cells
EZH2 is the catalytic subunit of PRC2, a central epigenetic repressor essential for development processes in vivo and for the differentiation of embryonic stem cells (ESCs) in vitro. The biochemical function of PRC2 in depositing repressive H3K27me3 marks is well understood, but how it is regulated...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3839660/ https://ncbi.nlm.nih.gov/pubmed/24141703 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2700 |
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