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PRC2 binds to active promoters and contacts nascent RNAs in embryonic stem cells

EZH2 is the catalytic subunit of PRC2, a central epigenetic repressor essential for development processes in vivo and for the differentiation of embryonic stem cells (ESCs) in vitro. The biochemical function of PRC2 in depositing repressive H3K27me3 marks is well understood, but how it is regulated...

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Main Authors: Kaneko, Syuzo, Son, Jinsook, Shen, Steven S., Reinberg, Danny, Bonasio, Roberto
格式: Artigo
語言:Inglês
出版: 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3839660/
https://ncbi.nlm.nih.gov/pubmed/24141703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2700
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