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Overexpression of heme oxygenase-1 in human pulmonary epithelial cells results in cell growth arrest and increased resistance to hyperoxia.

Heme oxygenase (HO) catalyzes the rate-limiting step in the degradation of heme to biliverdin, which is reduced by biliverdin reductase to bilirubin. Heme oxygenase-1 (HO-1) is inducible not only by its heme substrate, but also by a variety of agents causing oxidative stress. Although much is known...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Lee, P J, Alam, J, Wiegand, G W, Choi, A M
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1996
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38395/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8816811/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.19.10393
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