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Cytochrome P450 ω-hydroxylase promotes angiogenesis and metastasis by upregulation of VEGF and MMP-9 in non-small cell lung cancer

PURPOSE: Cytochrome P450 (CYP) ω-hydroxylase, mainly consisting of CYP4A and CYP4F, converts arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE) that induces angiogenic responses in vivo and in vitro. The present study examined the role of CYP ω-hydroxylase in angiogenesis and metastasis o...

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Autores principales: Yu, Wei, Chen, Li, Yang, Yu-Qing, Falck, John R., Guo, Austin M., Li, Ying, Yang, Jing
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3839420/
https://ncbi.nlm.nih.gov/pubmed/21120482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-010-1521-8
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