Mitofusin 2 in POMC Neurons Connects ER Stress with Leptin Resistance and Energy Imbalance

Mitofusin 2 (Mfn2) plays critical roles in both mitochondrial fusion and the establishment of mitochondria-endoplasmic reticulum (ER) interactions. Hypothalamic ER stress has emerged as a causative factor for the development of leptin resistance, but the underlying mechanisms are largely unknown. He...

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Autores principales: Schneeberger, Marc, Dietrich, Marcelo O, Sebastián, David, Imbernón, Mónica, Castaño, Carlos, Garcia, Ainhoa, Esteban, Yaiza, Gonzalez-Franquesa, Alba, Rodríguez, Ignacio Castrillón, Bortolozzi, Analía, Garcia-Roves, Pablo M, Gomis, Ramon, Nogueiras, Ruben, Horvath, Tamas L, Zorzano, Antonio, Claret, Marc
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3839088/
https://ncbi.nlm.nih.gov/pubmed/24074867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.09.003
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