Both mutated and unmutated memory B cells accumulate mutations in the course of the secondary response and develop a new antibody repertoire optimally adapted to the secondary stimulus

High-affinity memory B cells are preferentially selected during secondary responses and rapidly differentiate into antibody-producing cells. However, it remains unknown whether only high-affinity, mutated memory B cells simply expand to dominate the secondary response or if in fact memory B cells wi...

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Detalhes bibliográficos
Main Authors: Kaji, Tomohiro, Furukawa, Koji, Ishige, Akiko, Toyokura, Itsumi, Nomura, Masaki, Okada, Mariko, Takahashi, Yoshimasa, Shimoda, Michiko, Takemori, Toshitada
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3839062/
https://ncbi.nlm.nih.gov/pubmed/24021876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/intimm/dxt030
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