Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory

One component of memory in the antibody system is long-lived memory B cells selected for the expression of somatically mutated, high-affinity antibodies in the T cell–dependent germinal center (GC) reaction. A puzzling observation has been that the memory B cell compartment also contains cells expre...

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Hauptverfasser: Kaji, Tomohiro, Ishige, Akiko, Hikida, Masaki, Taka, Junko, Hijikata, Atsushi, Kubo, Masato, Nagashima, Takeshi, Takahashi, Yoshimasa, Kurosaki, Tomohiro, Okada, Mariko, Ohara, Osamu, Rajewsky, Klaus, Takemori, Toshitada
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3478929/
https://ncbi.nlm.nih.gov/pubmed/23027924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20120127
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