hERG1 channels modulate integrin signaling to trigger angiogenesis and tumor progression in colorectal cancer

Angiogenesis is a potential target for cancer therapy. We identified a novel signaling pathway that sustains angiogenesis and progression in colorectal cancer (CRC). This pathway is triggered by β(1) integrin-mediated adhesion and leads to VEGF-A secretion. The effect is modulated by the human ether...

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Détails bibliographiques
Auteurs principaux: Crociani, Olivia, Zanieri, Francesca, Pillozzi, Serena, Lastraioli, Elena, Stefanini, Matteo, Fiore, Antonella, Fortunato, Angelo, D'Amico, Massimo, Masselli, Marika, De Lorenzo, Emanuele, Gasparoli, Luca, Chiu, Martina, Bussolati, Ovidio, Becchetti, Andrea, Arcangeli, Annarosa
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2013
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3839040/
https://ncbi.nlm.nih.gov/pubmed/24270902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep03308
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