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Potent Inhibition of the C-P Lyase Nucleosidase PhnI by ImmucillinA-Triphosphate

The C-P lyase complex in bacteria catalyzes the transformation of phosphonates to orthophosphate under conditions of phosphate starvation. The first committed step in the C-P lyase catalyzed reaction is the displacement of adenine from MgATP by phosphonate substrates to yield ribose-1-phosphonate-5-...

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Autors principals: Kamat, Siddhesh S., Burgos, Emmanuel S., Raushel, Frank M.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3838859/
https://ncbi.nlm.nih.gov/pubmed/24111876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi4013287
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