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Pyrazoles as inhibitors of alcohol oxidation and as important tools in alcohol research: An approach to therapy against methanol poisoning

4-Methylpyrazole, in a dose producing inhibition of alcohol dehydrogenase (alcohol:NAD(+) oxidoreductase, EC 1.1.1.1), was given alone or together with ethanol (10%) as sole drinking fluid to growing rats for up to 38 weeks. Their weight curves remained normal. Electron microscopy of liver, kidney,...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Blomstrand, Rolf, Östling-Wintzell, Helene, Löf, Agneta, McMartin, Kenneth, Tolf, Bo-Ragnar, Hedström, Karl-Göran
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1979
Fag:
Biological Sciences: Medical Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC383854/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/115004/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.76.7.3499
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