A Broad Phenotypic Screen Identifies Novel Phenotypes Driven by a Single Mutant Allele in Huntington’s Disease CAG Knock-In Mice

Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder caused by the expansion of a CAG trinucleotide repeat in the HTT gene encoding huntingtin. The disease has an insidious course, typically progressing over 10-15 years until death. Currently there is no effective disease-mo...

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Hauptverfasser: Hölter, Sabine M., Stromberg, Mary, Kovalenko, Marina, Garrett, Lillian, Glasl, Lisa, Lopez, Edith, Guide, Jolene, Götz, Alexander, Hans, Wolfgang, Becker, Lore, Rathkolb, Birgit, Rozman, Jan, Schrewed, Anja, Klingenspor, Martin, Klopstock, Thomas, Schulz, Holger, Wolf, Eckhard, Wursta, Wolfgang, Gillis, Tammy, Wakimoto, Hiroko, Seidman, Jonathan, MacDonald, Marcy E., Cotman, Susan, Gailus-Durner, Valérie, Fuchs, Helmut, de Angelis, Martin Hrabě, Lee, Jong-Min, Wheeler, Vanessa C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3838378/
https://ncbi.nlm.nih.gov/pubmed/24278347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0080923
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