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Replication Stress and Mitotic Dysfunction in Cells Expressing Simian Virus 40 Large T Antigen

We previously demonstrated that simian virus 40 (SV40) large T antigen (LT) binds to the Bub1 kinase, a key regulator of the spindle checkpoint and chromosome segregation. Bub1 mutations or altered expression patterns are linked to chromosome missegregation and are considered to be a driving force i...

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Detalhes bibliográficos
Main Authors: Hu, Liang, Filippakis, Harilaos, Huang, Haomin, Yen, Timothy J., Gjoerup, Ole V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3838287/
https://ncbi.nlm.nih.gov/pubmed/24067972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02224-13
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