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Mutations in the Parainfluenza Virus 5 Fusion Protein Reveal Domains Important for Fusion Triggering and Metastability

Paramyxovirus membrane glycoproteins F (fusion protein) and HN, H, or G (attachment protein) are critical for virus entry, which occurs through fusion of viral and cellular envelopes. The F protein folds into a homotrimeric, metastable prefusion form that can be triggered by the attachment protein t...

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Autors principals: Bose, Sayantan, Heath, Carissa M., Shah, Priya A., Alayyoubi, Maher, Jardetzky, Theodore S., Lamb, Robert A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3838234/
https://ncbi.nlm.nih.gov/pubmed/24089572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02123-13
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