Comparison of Next-Generation Sequencing and Clone-Based Sequencing in Analysis of Hepatitis B Virus Reverse Transcriptase Quasispecies Heterogeneity

We previously reported that, based on clone-based sequencing (CBS), hepatitis B virus (HBV) heterogeneity within the reverse transcriptase (RT) region was a predictor of antiviral efficacy. Here, by comparing ultradeep pyrosequencing (UDPS), i.e., next-generation sequencing (NGS), with CBS in charac...

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Detalhes bibliográficos
Main Authors: Gong, Ling, Han, Yue, Chen, Li, Liu, Feng, Hao, Pei, Sheng, Jia, Li, Xin-Hua, Yu, De-Min, Gong, Qi-Ming, Tian, Fei, Guo, Xiao-kui, Zhang, Xin-Xin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Virology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3838070/
https://ncbi.nlm.nih.gov/pubmed/24088859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.01723-13
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