Characterization of a Novel Fusion Protein from IpaB and IpaD of Shigella spp. and Its Potential as a Pan-Shigella Vaccine

Shigellosis is an important disease in the developing world, where about 90 million people become infected with Shigella spp. each year. We previously demonstrated that the type three secretion apparatus (T3SA) proteins IpaB and IpaD are protective antigens in the mouse lethal pulmonary model. In or...

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Autori principali: Martinez-Becerra, Francisco J., Chen, Xiaotong, Dickenson, Nicholas E., Choudhari, Shyamal P., Harrison, Kelly, Clements, John D., Picking, William D., Van De Verg, Lillian L., Walker, Richard I., Picking, Wendy L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2013
Soggetti:
Microbial Immunity and Vaccines
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837967/
https://ncbi.nlm.nih.gov/pubmed/24060976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00859-13
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