Discovery of Inhibitors of 4′-Phosphopantetheine Adenylyltransferase (PPAT) To Validate PPAT as a Target for Antibacterial Therapy

Inhibitors of 4′-phosphopantetheine adenylyltransferase (PPAT) were identified through high-throughput screening of the AstraZeneca compound library. One series, cycloalkyl pyrimidines, showed inhibition of PPAT isozymes from several species, with the most potent inhibition of enzymes from Gram-posi...

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Detaylı Bibliyografya
Asıl Yazarlar: de Jonge, Boudewijn L. M., Walkup, Grant K., Lahiri, Sushmita D., Huynh, Hoan, Neckermann, Georg, Utley, Luke, Nash, Tory J., Brock, Jesse, San Martin, Maryann, Kutschke, Amy, Johnstone, Michele, Laganas, Valerie, Hajec, Laurel, Gu, Rong-Fang, Ni, Haihong, Chen, Brendan, Hutchings, Kim, Holt, Elise, McKinney, David, Gao, Ning, Livchak, Stephania, Thresher, Jason
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2013
Konular:
Experimental Therapeutics
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837906/
https://ncbi.nlm.nih.gov/pubmed/24041904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01661-13
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