Discovery of Inhibitors of 4′-Phosphopantetheine Adenylyltransferase (PPAT) To Validate PPAT as a Target for Antibacterial Therapy

Inhibitors of 4′-phosphopantetheine adenylyltransferase (PPAT) were identified through high-throughput screening of the AstraZeneca compound library. One series, cycloalkyl pyrimidines, showed inhibition of PPAT isozymes from several species, with the most potent inhibition of enzymes from Gram-posi...

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Bibliografiska uppgifter
Huvudupphovsmän: de Jonge, Boudewijn L. M., Walkup, Grant K., Lahiri, Sushmita D., Huynh, Hoan, Neckermann, Georg, Utley, Luke, Nash, Tory J., Brock, Jesse, San Martin, Maryann, Kutschke, Amy, Johnstone, Michele, Laganas, Valerie, Hajec, Laurel, Gu, Rong-Fang, Ni, Haihong, Chen, Brendan, Hutchings, Kim, Holt, Elise, McKinney, David, Gao, Ning, Livchak, Stephania, Thresher, Jason
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2013
Ämnen:
Experimental Therapeutics
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837906/
https://ncbi.nlm.nih.gov/pubmed/24041904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01661-13
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