Discovery of Inhibitors of 4′-Phosphopantetheine Adenylyltransferase (PPAT) To Validate PPAT as a Target for Antibacterial Therapy

Inhibitors of 4′-phosphopantetheine adenylyltransferase (PPAT) were identified through high-throughput screening of the AstraZeneca compound library. One series, cycloalkyl pyrimidines, showed inhibition of PPAT isozymes from several species, with the most potent inhibition of enzymes from Gram-posi...

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Main Authors: de Jonge, Boudewijn L. M., Walkup, Grant K., Lahiri, Sushmita D., Huynh, Hoan, Neckermann, Georg, Utley, Luke, Nash, Tory J., Brock, Jesse, San Martin, Maryann, Kutschke, Amy, Johnstone, Michele, Laganas, Valerie, Hajec, Laurel, Gu, Rong-Fang, Ni, Haihong, Chen, Brendan, Hutchings, Kim, Holt, Elise, McKinney, David, Gao, Ning, Livchak, Stephania, Thresher, Jason
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2013
Assuntos:
Experimental Therapeutics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837906/
https://ncbi.nlm.nih.gov/pubmed/24041904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01661-13
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