Discovery of Inhibitors of 4′-Phosphopantetheine Adenylyltransferase (PPAT) To Validate PPAT as a Target for Antibacterial Therapy

Inhibitors of 4′-phosphopantetheine adenylyltransferase (PPAT) were identified through high-throughput screening of the AstraZeneca compound library. One series, cycloalkyl pyrimidines, showed inhibition of PPAT isozymes from several species, with the most potent inhibition of enzymes from Gram-posi...

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Autores principales: de Jonge, Boudewijn L. M., Walkup, Grant K., Lahiri, Sushmita D., Huynh, Hoan, Neckermann, Georg, Utley, Luke, Nash, Tory J., Brock, Jesse, San Martin, Maryann, Kutschke, Amy, Johnstone, Michele, Laganas, Valerie, Hajec, Laurel, Gu, Rong-Fang, Ni, Haihong, Chen, Brendan, Hutchings, Kim, Holt, Elise, McKinney, David, Gao, Ning, Livchak, Stephania, Thresher, Jason
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2013
Materias:
Experimental Therapeutics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837906/
https://ncbi.nlm.nih.gov/pubmed/24041904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01661-13
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