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Antifungal Prophylaxis with Posaconazole in Patients with Acute Myeloid Leukemia: Dose Intensification Coupled with Avoidance of Proton Pump Inhibitors Is Beneficial in Shortening Time to Effective Concentrations

This study aimed to assess the influence of dose frequency and the presence or absence of cotreatment with proton pump inhibitors (PPIs) on the time to a target trough concentration (C(min)) of >700 ng/ml with posaconazole in the first 8 days of antifungal prophylaxis in hematological patients. T...

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Detalhes bibliográficos
Main Authors: Cojutti, Piergiorgio, Candoni, Anna, Simeone, Erica, Franceschi, Loretta, Fanin, Renato, Pea, Federico
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837868/
https://ncbi.nlm.nih.gov/pubmed/24060872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01586-13
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