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Gallium Nitrate Is Efficacious in Murine Models of Tuberculosis and Inhibits Key Bacterial Fe-Dependent Enzymes

Acquiring iron (Fe) is critical to the metabolism and growth of Mycobacterium tuberculosis. Disruption of Fe metabolism is a potential approach for novel antituberculous therapy. Gallium (Ga) has many similarities to Fe. Biological systems are often unable to distinguish Ga(3+) from Fe(3+). Unlike F...

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Main Authors: Olakanmi, Oyebode, Kesavalu, Banurekha, Pasula, Rajamouli, Abdalla, Maher Y., Schlesinger, Larry S., Britigan, Bradley E.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2013
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גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837848/
https://ncbi.nlm.nih.gov/pubmed/24060870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01543-13
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