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The Arg92Cys colipase polymorphism impairs function and secretion by increasing protein misfolding
Colipase is essential for efficient fat digestion. An arginine-to-cysteine polymorphism at position 92 of colipase (Arg92Cys) associates with an increased risk for developing type-2 diabetes through an undefined mechanism. To test our hypothesis that the extra cysteine increases colipase misfolding,...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3837459/ https://ncbi.nlm.nih.gov/pubmed/23204298 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M034066 |
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