HCV NS3 protease enhances liver fibrosis via binding to and activating TGF-β type I receptor

Viruses sometimes mimic host proteins and hijack the host cell machinery. Hepatitis C virus (HCV) causes liver fibrosis, a process largely mediated by the overexpression of transforming growth factor (TGF)-β and collagen, although the precise underlying mechanism is unknown. Here, we report that HCV...

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Detalhes bibliográficos
Main Authors: Sakata, Kotaro, Hara, Mitsuko, Terada, Takaho, Watanabe, Noriyuki, Takaya, Daisuke, Yaguchi, So-ichi, Matsumoto, Takehisa, Matsuura, Tomokazu, Shirouzu, Mikako, Yokoyama, Shigeyuki, Yamaguchi, Tokio, Miyazawa, Keiji, Aizaki, Hideki, Suzuki, Tetsuro, Wakita, Takaji, Imoto, Masaya, Kojima, Soichi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837337/
https://ncbi.nlm.nih.gov/pubmed/24263861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep03243
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