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The Emerging Role of the Phosphatidylinositol 3-Kinase/ Akt/Mammalian Target of Rapamycin Signaling Network in Cancer Stem Cell Biology

The cancer stem cell theory entails the existence of a hierarchically organized, rare population of cells which are responsible for tumor initiation, self-renewal/maintenance, and mutation accumulation. The cancer stem cell proposition could explain the high frequency of cancer relapse and resistanc...

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Hlavní autoři: Martelli, Alberto M., Evangelisti, Camilla, Chiarini, Francesca, Grimaldi, Cecilia, McCubrey, James A.
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837323/
https://ncbi.nlm.nih.gov/pubmed/24281174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers2031576
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