Two hits are better than one: targeting both phosphatidylinositol 3-kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia treatment

Phosphatidylinositol 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) are two key components of the PI3K/Akt/mTOR signaling pathway. This signal transduction cascade regulates a wide range of physiological cell processes, that include differentiation, proliferation, apoptosis, autophagy, met...

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Hauptverfasser: Martelli, Alberto M., Chiarini, Francesca, Evangelisti, Camilla, Cappellini, Alessandra, Buontempo, Francesca, Bressanin, Daniela, Fini, Milena, McCubrey, James A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2012
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3380573/
https://ncbi.nlm.nih.gov/pubmed/22564882
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