DNA promoter methylation in breast tumors: No association with genetic polymorphisms in MTHFR and MTR

Aberrant promoter methylation is recognized as an important feature of breast carcinogenesis. We hypothesized that genetic variation of genes for methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MTR), two critical enzymes in one-carbon metabolism, may alter DNA methylation levels...

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Autori principali: Tao, Meng Hua, Shields, Peter G., Nie, Jing, Marian, Catalin, Ambrosone, Christine B., McCann, Susan E., Platek, Mary, Krishnan, Shiva S., Xie, Bin, Edge, Stephen B., Winston, Janet, Vito, Dominica, Trevisan, Maurizio, Freudenheim, Jo L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837294/
https://ncbi.nlm.nih.gov/pubmed/19240236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1055-9965.EPI-08-0916
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