Low BRAF and NRAS expression levels are associated with clinical benefit from DTIC therapy and prognosis in metastatic melanoma

Metastatic melanoma is characterized by a poor response to chemotherapy. Furthermore, there is a lack of established predictive and prognostic markers. In this single institution study, we correlated mutation status and expression levels of BRAF and NRAS to dacarbazine (DTIC) treatment response as w...

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Autori principali: Birkeland, Einar, Busch, Christian, Berge, Elisabet Ognedal, Geisler, Jürgen, Jönsson, Göran, Lillehaug, Johan Richard, Knappskog, Stian, Lønning, Per Eystein
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Netherlands 2013
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837233/
https://ncbi.nlm.nih.gov/pubmed/23673558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10585-013-9587-4
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