Impaired Phosphorylation and Ubiquitination by p70 S6 Kinase (p70S6K) and Smad Ubiquitination Regulatory Factor 1 (Smurf1) Promote Tribbles Homolog 2 (TRIB2) Stability and Carcinogenic Property in Liver Cancer

Tribbles homolog 2 (TRIB2) is critical for both solid and non-solid malignancies. Recently, TRIB2 was identified as a liver cancer-specific Wnt/β-catenin signaling downstream target and is functionally important for liver cancer cell survival and transformation. TRIB2 functions as a protein that int...

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Autori principali: Wang, Jiayi, Zhang, Yue, Weng, Wenhao, Qiao, Yongxia, Ma, Lifang, Xiao, Weifan, Yu, Yongchun, Pan, Qiuhui, Sun, Fenyong
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2013
Soggetti:
Gene Regulation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837113/
https://ncbi.nlm.nih.gov/pubmed/24089522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.503292
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