p62/Sequestosome-1 Up-regulation Promotes ABT-263-induced Caspase-8 Aggregation/Activation on the Autophagosome

Autophagy and apoptosis regulate cancer cell viability in response to cytotoxic stress; however, their functional relationship remains unclear. p62/sequestosome 1 is a multifunctional protein and a signaling hub that shuttles ubiquitinated proteins to the lysosome during autophagy. Autophagy inhibit...

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Bibliographic Details
Main Authors: Huang, Shengbing, Okamoto, Koichi, Yu, Chunrong, Sinicrope, Frank A.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837112/
https://ncbi.nlm.nih.gov/pubmed/24121507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.518134
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