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Diminished Adenosine A1 Receptor Expression in Pancreatic α-Cells May Contribute to the Pathology of Type 1 Diabetes

Prediabetic NOD mice exhibit hyperglucagonemia, possibly due to an intrinsic α-cell defect. Here, we show that the expression of a potential glucagon inhibitor, the adenosine A1 receptor (Adora1), is gradually diminished in α-cells of NOD mice, autoantibody-positive (AA(+)) and overtly type 1 diabet...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Yip, Linda, Taylor, Cariel, Whiting, Chan C., Fathman, C. Garrison
פורמט: Artigo
שפה:Inglês
יצא לאור: American Diabetes Association 2013
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837064/
https://ncbi.nlm.nih.gov/pubmed/24264405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-0614
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