Peroxynitrite-Dependent Zinc Release and Inactivation of Guanosine 5′-Triphosphate Cyclohydrolase 1 Instigate Its Ubiquitination in Diabetes

Aberrant degradation of guanosine 5′-triphosphate cyclohydrolase 1 (GTPCH1) with consequent deficiency of tetrahydrobiopterin is considered the primary cause for endothelial dysfunction in diabetes. How GTPCH1 becomes susceptible to the degradation remains unknown. We hypothesized that oxidation and...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Zhao, Yu, Wu, Jiliang, Zhu, Huaiping, Song, Ping, Zou, Ming-Hui
Format: Artigo
Sprog:Inglês
Udgivet: American Diabetes Association 2013
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837037/
https://ncbi.nlm.nih.gov/pubmed/23974923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-0751
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker