Role of Increased Guanosine Triphosphate Cyclohydrolase-1 Expression and Tetrahydrobiopterin Levels upon T Cell Activation

Tetrahydrobiopterin (BH(4)) is an essential co-factor for the nitric-oxide (NO) synthases, and in its absence these enzymes produce superoxide (O(2)(˙̄)) rather than NO. The rate-limiting enzyme for BH(4) production is guanosine triphosphate cyclohydrolase-1 (GTPCH-1). Because endogenously produced...

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Detalhes bibliográficos
Main Authors: Chen, Wei, Li, Li, Brod, Torben, Saeed, Omar, Thabet, Salim, Jansen, Thomas, Dikalov, Sergey, Weyand, Cornelia, Goronzy, Jorg, Harrison, David G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077585/
https://ncbi.nlm.nih.gov/pubmed/21343293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.191023
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