Role of Increased Guanosine Triphosphate Cyclohydrolase-1 Expression and Tetrahydrobiopterin Levels upon T Cell Activation

Tetrahydrobiopterin (BH(4)) is an essential co-factor for the nitric-oxide (NO) synthases, and in its absence these enzymes produce superoxide (O(2)(˙̄)) rather than NO. The rate-limiting enzyme for BH(4) production is guanosine triphosphate cyclohydrolase-1 (GTPCH-1). Because endogenously produced...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Chen, Wei, Li, Li, Brod, Torben, Saeed, Omar, Thabet, Salim, Jansen, Thomas, Dikalov, Sergey, Weyand, Cornelia, Goronzy, Jorg, Harrison, David G.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2011
Matèries:
Molecular Bases of Disease
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077585/
https://ncbi.nlm.nih.gov/pubmed/21343293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.191023
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars