Hepatic Notch Signaling Correlates With Insulin Resistance and Nonalcoholic Fatty Liver Disease

Hepatic Notch signaling is inappropriately activated in obese/insulin-resistant mouse models. Genetic or pharmacologic inhibition of hepatic Notch signaling in obese mice simultaneously improves glucose tolerance and reduces hepatic triglyceride content. As such, we predicted that Notch signaling in...

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Autors principals: Valenti, Luca, Mendoza, Rosa M., Rametta, Raffaela, Maggioni, Marco, Kitajewski, Chris, Shawber, Carrie J., Pajvani, Utpal B.
Format: Artigo
Idioma:Inglês
Publicat: American Diabetes Association 2013
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837035/
https://ncbi.nlm.nih.gov/pubmed/23990360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-0769
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