Hepatic Notch Signaling Correlates With Insulin Resistance and Nonalcoholic Fatty Liver Disease

Hepatic Notch signaling is inappropriately activated in obese/insulin-resistant mouse models. Genetic or pharmacologic inhibition of hepatic Notch signaling in obese mice simultaneously improves glucose tolerance and reduces hepatic triglyceride content. As such, we predicted that Notch signaling in...

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Hlavní autoři: Valenti, Luca, Mendoza, Rosa M., Rametta, Raffaela, Maggioni, Marco, Kitajewski, Chris, Shawber, Carrie J., Pajvani, Utpal B.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2013
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837035/
https://ncbi.nlm.nih.gov/pubmed/23990360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-0769
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