Quantitative Identification of Mutant Alleles Derived from Lung Cancer in Plasma Cell-Free DNA via Anomaly Detection Using Deep Sequencing Data

The detection of rare mutants using next generation sequencing has considerable potential for diagnostic applications. Detecting circulating tumor DNA is the foremost application of this approach. The major obstacle to its use is the high read error rate of next-generation sequencers. Rather than in...

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Main Authors: Kukita, Yoji, Uchida, Junji, Oba, Shigeyuki, Nishino, Kazumi, Kumagai, Toru, Taniguchi, Kazuya, Okuyama, Takako, Imamura, Fumio, Kato, Kikuya
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836767/
https://ncbi.nlm.nih.gov/pubmed/24278442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0081468
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