A Unique SUMO-2-Interacting Motif within LANA Is Essential for KSHV Latency

Kaposi's sarcoma-associated herpesvirus (KSHV) stabilizes hypoxia-inducible factor α (HIF-1α) during latent infection, and HIF-1α reactivates lytic replication under hypoxic stress. However, the mechanism utilized by KSHV to block lytic reactivation with the accumulation of HIF-1α in latency re...

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Bibliographic Details
Main Authors: Cai, Qiliang, Cai, Shen, Zhu, Caixia, Verma, Suhbash C., Choi, Ji-Young, Robertson, Erle S.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836728/
https://ncbi.nlm.nih.gov/pubmed/24278015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003750
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