A Small Molecule Glycosaminoglycan Mimetic Blocks Plasmodium Invasion of the Mosquito Midgut

Malaria transmission-blocking (T-B) interventions are essential for malaria elimination. Small molecules that inhibit the Plasmodium ookinete-to-oocyst transition in the midgut of Anopheles mosquitoes, thereby blocking sporogony, represent one approach to achieving this goal. Chondroitin sulfate gly...

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Main Authors: Mathias, Derrick K., Pastrana-Mena, Rebecca, Ranucci, Elisabetta, Tao, Dingyin, Ferruti, Paolo, Ortega, Corrie, Staples, Gregory O., Zaia, Joseph, Takashima, Eizo, Tsuboi, Takafumi, Borg, Natalie A., Verotta, Luisella, Dinglasan, Rhoel R.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836724/
https://ncbi.nlm.nih.gov/pubmed/24278017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003757
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