Loss of DNMT1o Disrupts Imprinted X Chromosome Inactivation and Accentuates Placental Defects in Females

The maintenance of key germline derived DNA methylation patterns during preimplantation development depends on stores of DNA cytosine methyltransferase-1o (DNMT1o) provided by the oocyte. Dnmt1o(mat−/−) mouse embryos born to Dnmt1(Δ1o/Δ1o) female mice lack DNMT1o protein and have disrupted genomic i...

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Autores principales: McGraw, Serge, Oakes, Christopher C., Martel, Josée, Cirio, M. Cecilia, de Zeeuw, Pauline, Mak, Winifred, Plass, Christoph, Bartolomei, Marisa S., Chaillet, J. Richard, Trasler, Jacquetta M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836718/
https://ncbi.nlm.nih.gov/pubmed/24278026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003873
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