Ribosome Synthesis and MAPK Activity Modulate Ionizing Radiation-Induced Germ Cell Apoptosis in Caenorhabditis elegans

Synthesis of ribosomal RNA by RNA polymerase I (RNA pol I) is an elemental biological process and is key for cellular homeostasis. In a forward genetic screen in C. elegans designed to identify DNA damage-response factors, we isolated a point mutation of RNA pol I, rpoa-2(op259), that leads to alter...

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Detalhes bibliográficos
Main Authors: Eberhard, Ralf, Stergiou, Lilli, Hofmann, E. Randal, Hofmann, Jen, Haenni, Simon, Teo, Youjin, Furger, André, Hengartner, Michael O.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836707/
https://ncbi.nlm.nih.gov/pubmed/24278030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003943
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