Genome-wide siRNA screen reveals a new cellular partner of NK cell receptor KIR2DL4: heparan sulfate directly modulates KIR2DL4-mediated responses

KIR2DL4 (CD158d) is a distinct member of the killer cell Ig-like receptor (KIR) family in human NK cells that can induce cytokine production and cytolytic activity in resting NK cells. Soluble HLA-G, normally expressed only by fetal-derived trophoblast cells, was reported to be a ligand for KIR2DL4;...

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Main Authors: Brusilovsky, Michael, Cordoba, Moti, Rosental, Benyamin, Hershkovitz, Oren, Andrake, Mark D., Pecherskaya, Anna, Einarson, Margret B., Zhou, Yan, Braiman, Alex, Campbell, Kerry S., Porgador, Angel
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836631/
https://ncbi.nlm.nih.gov/pubmed/24127555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1302079
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