Pharmacologic Profiling of Phosphoinositide 3-Kinase Inhibitors as Mitigators of Ionizing Radiation–Induced Cell Death

Ionizing radiation (IR) induces genotoxic stress that triggers adaptive cellular responses, such as activation of the phosphoinositide 3-kinase (PI3K)/Akt signaling cascade. Pluripotent cells are the most important population affected by IR because they are required for cellular replenishment. Despi...

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Autors principals: Lazo, John S., Sharlow, Elizabeth R., Epperly, Michael W., Lira, Ana, Leimgruber, Stephanie, Skoda, Erin M., Wipf, Peter, Greenberger, Joel S.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2013
Matèries:
Drug Discovery and Translational Medicine
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836314/
https://ncbi.nlm.nih.gov/pubmed/24068833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.113.208421
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