DUAL INHIBITION OF CLASS IA PHOSPHATIDYLINOSITOL 3-KINASE AND mTOR AS A NEW THERAPEUTIC OPTION FOR T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA

Recent investigations have documented that constitutively activated phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian Target of Rapamycin (mTOR) signaling is a common feature of T-cell acute lymphoblastic leukemia (T-ALL) where it strongly influences growth and survival. These findings lend compell...

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Detalhes bibliográficos
Main Authors: Chiarini, Francesca, Falà, Federica, Tazzari, Pier Luigi, Ricci, Francesca, Astolfi, Annalisa, Pession, Andrea, Pagliaro, Pasqualepaolo, McCubrey, James A., Martelli, Alberto M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836286/
https://ncbi.nlm.nih.gov/pubmed/19351820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-4884
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