Mathematical Modeling of Oncogenesis Control in Mature T-Cell Populations

T-cell receptor (TCR) polyclonal mature T cells are surprisingly resistant to oncogenic transformation after retroviral insertion of T-cell oncogenes. In a mouse model, it has been shown that mature T-cell lymphoma/leukemia (MTCLL) is not induced upon transplantation of mature, TCR polyclonal wild-t...

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Main Authors: Gerdes, Sebastian, Newrzela, Sebastian, Glauche, Ingmar, von Laer, Dorothee, Hansmann, Martin-Leo, Roeder, Ingo
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2013
Assuntos:
Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836208/
https://ncbi.nlm.nih.gov/pubmed/24409176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2013.00380
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