DHEA-Mediated Inhibition of the Pentose Phosphate Pathway Alters Oocyte Lipid Metabolism in Mice

Women with polycystic ovary syndrome (PCOS) and hyperandrogenism have altered hormone levels and suffer from ovarian dysfunction leading to subfertility. We have attempted to generate a model of hyperandrogenism by feeding mice chow supplemented with dehydroepiandrosterone (DHEA), an androgen precur...

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Autori principali: Jimenez, Patricia T., Frolova, Antonina I., Chi, Maggie M., Grindler, Natalia M., Willcockson, Alexandra R., Reynolds, Kasey A., Zhao, Quihong, Moley, Kelle H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Endocrine Society 2013
Soggetti:
Reproduction-Development
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836065/
https://ncbi.nlm.nih.gov/pubmed/24036000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2012-2140
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